Spravato® vs. IV Ketamine Therapy: What’s the Difference and Which Is Right for You?
At Sturges Family Practice, we’re committed to offering advanced, evidence-based treatments for mental health conditions like treatment-resistant depression (TRD), PTSD, and anxiety. Two of the most innovative options available today are Spravato® (esketamine) and IV ketamine therapy.
While both treatments have shown remarkable results for patients who haven’t found relief with traditional medications, they differ in key ways. Here’s what you need to know to make an informed decision about your care.
What Is Spravato®?
Spravato® is the brand name for esketamine, a form of ketamine approved by the FDA in 2019 specifically for treatment-resistant depression and major depressive disorder with suicidal thoughts. It’s administered as a nasal spray in a certified healthcare setting, like our clinic.
How it works: Spravato targets NMDA receptors in the brain, helping to restore healthy neural connections and improve mood.
Administration: Patients self-administer the nasal spray under medical supervision and remain at the clinic for at least two hours post-treatment.
Treatment schedule: Usually twice a week for the first month, then less frequently based on progress.
Insurance coverage: Often covered by insurance for qualifying conditions.
What Is IV Ketamine Therapy?
IV ketamine therapy uses racemic ketamine (a combination of two mirror-image molecules, including esketamine) delivered directly into the bloodstream through an intravenous (IV) infusion. This method has been used off-label for years to treat a range of mood disorders.
How it works: Like Spravato, IV ketamine acts on NMDA receptors but may also influence other neural pathways, potentially offering broader benefits.
Administration: The infusion typically lasts 40-60 minutes, followed by a short observation period in the clinic.
Treatment schedule: Often involves a series of 6 infusions over 2–3 weeks, followed by maintenance sessions as needed.
Insurance coverage: Often considered off-label, so coverage can be limited.
Which One Is Right for You?
Choosing between Spravato and IV ketamine depends on several factors, including:
Your diagnosis and treatment history
Insurance coverage and financial considerations
How your body responds to different delivery methods
Whether you have co-occurring conditions that make one method safer than the other
At Sturges Family Practice, our experienced team will work with you to develop a treatment plan tailored to your unique needs. We’ll guide you through every step of the process—from initial assessment to monitoring your progress and adjusting care as needed.
Ready to Take the Next Step?
If you or a loved one is struggling with depression that hasn’t responded to traditional therapies, Spravato or IV ketamine may offer a new path forward. Contact Sturges Family Practice at 208-665-5596 to schedule a consultation and find out which option is right for you.
